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GABA transaminase (ABAT) Rabbit Polyclonal Antibody (CAB5299)

SKU:
CAB5299
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience
  • Neuroscience Anti-ABAT Antibody CAB5299
  • Neuroscience Anti-ABAT Antibody CAB5299
  • Neuroscience Anti-ABAT Antibody CAB5299
  • Neuroscience Anti-ABAT Antibody CAB5299
  • Neuroscience Anti-ABAT Antibody CAB5299
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:GABA transaminase (ABAT) Rabbit Polyclonal Antibody
SKU:CAB5299
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-300 of human GABA transaminase (GABA transaminase (ABAT)) (NP_001120920.1).
Sequence:SQAA AKVD VEFD YDGP LMKT EVPG PRSQ ELMK QLNI IQNA EAVH FFCN YEES RGNY LVDV DGNR MLDL YSQI SSVP IGYS HPAL LKLI QQPQ NASM FVNR PALG ILPP ENFV EKLR QSLL SVAP KGMS QLIT MACG SCSN ENAL KTIF MWYR SKER GQRG FSQE ELET CMIN QAPG CPDY SILS FMGA FHGR TMGC LATT HSKA IHKI DIPS FDWP IAPF PRLK YPLE EFVK ENQQ EEAR CLEE VEDL IVKY RKKK KTVA GIIV EPIQ SEGG
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:GABAT; NPD009; GABA-AT; GABA transaminase (ABAT)
Positive Sample:HepG2,Mouse kidney,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Mitochondrion matrix.
Calculated MW:56kDa
Observed MW:50kDa

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Purification Method:Affinity purification
Gene ID:18
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using GABA transaminase (ABAT) Rabbit pAb (CAB5299) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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