ABCB7 Rabbit Polyclonal Antibody (CAB14699)
- SKU:
- CAB14699
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Product Name: | ABCB7 Rabbit Polyclonal Antibody |
| SKU: | CAB14699 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 503-753 of human ABCB7 (NP_004290.2). |
| Sequence: | AIVG GSGS GKST IVRL LFRF YEPQ KGSI YLAG QNIQ DVSL ESLR RAVG VVPQ DAVL FHNT IYYN LLYG NISA SPEE VYAV AKLA GLHD AILR MPHG YDTQ VGER GLKL SGGE KQRV AIAR AILK DPPV ILYD EATS SLDS ITEE TILG AMKD VVKH RTSI FIAH RLST VVDA DEII VLDQ GKVA ERGT HHGL LANP HSIY SEMW HTQS SRVQ NHDN PKWE AKKE NISK EEER KKLQ EEIV NSVK GCGN CSC |
| Tested Applications: | WB IHC-P IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
| Synonyms: | ABC7; ASAT; Atm1p; EST140535; ABCB7 |
| Positive Sample: | A-431,293T,Mouse heart |
| Conjugate: | Unconjugated |
| Cellular Localization: | Mitochondrion inner membrane, Multi-pass membrane protein. |
| Calculated MW: | 83kDa |
| Observed MW: | 83kDa |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Purification Method: | Affinity purification |
| Gene ID: | 22 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using ABCB7 Rabbit pAb (CAB14699) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s. |
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