ABCC1 Rabbit Polyclonal Antibody (CAB11153)
- SKU:
- CAB11153
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Product Name: | ABCC1 Rabbit Polyclonal Antibody |
| SKU: | CAB11153 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-960 of human MRP1/ABCC1 (NP_004987.2). |
| Sequence: | GSYQ ELLA RDGA FAEF LRTY ASTE QEQD AEEN GVTG VSGP GKEA KQME NGML VTDS AGKQ LQRQ LSSS SSYS GDIS RHHN STAE LQKA EAKK EETW KLME ADKA QTGQ VKL |
| Tested Applications: | WB ELISA |
| Recommended Dilution: | WB,1:500 - 1:2000 |
| Synonyms: | MRP; ABCC; GS-X; MRP1; ABC29; DFNA77; MRP1/ABCC1 |
| Positive Sample: | HepG2,HeLa |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
| Calculated MW: | 172kDa |
| Observed MW: | 210kDa |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
| Purification Method: | Affinity purification |
| Gene ID: | 4363 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
 | Western blot analysis of extracts of HepG2 cells, using MRP1/ABCC1 antibody (CAB11153) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s. |
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