Acetyl-NFE4 (K43) Antibody (PACO06074)
- SKU:
- PACO06074
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Acetyl-NFE4 (K43) Antibody (PACO06074) |
| Antibody SKU: | PACO06074 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the human NF-E4 around the acetylation site of K43. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of AD-293 cells using Acetyl-NF-E4 (K43) Polyclonal Antibody. |
 | Western Blot analysis of AD-293 cells using Acetyl-NF-E4 (K43) Polyclonal Antibody. |
| Synonyms: | NFE4; Transcription factor NF-E4 |
| UniProt Protein Function: | NF-E4: Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. 2 isoforms of the human protein are produced by alternative initiation.Chromosomal Location of Human Ortholog: 7q22.1 |
| UniProt Protein Details: | |
| NCBI Summary: | The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86UQ8 |
| NCBI GenInfo Identifier: | 74714021 |
| NCBI Gene ID: | 58160 |
| NCBI Accession: | Q86UQ8.1 |
| UniProt Secondary Accession: | Q86UQ8 |
| UniProt Related Accession: | Q86UQ8 |
| Molecular Weight: | 8,356 Da |
| NCBI Full Name: | Transcription factor NF-E4 |
| NCBI Synonym Full Names: | nuclear factor, erythroid 4 |
| NCBI Official Symbol: | NFE4Â Â |
| NCBI Official Synonym Symbols: | NF-E4Â Â |
| NCBI Protein Information: | transcription factor NF-E4 |
| UniProt Protein Name: | Transcription factor NF-E4 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | NFE4Â Â |
| UniProt Entry Name: | NFE4_HUMAN |
Related Products
