The ACMSD Polyclonal Antibody (CAB15953) is a valuable tool for researchers studying ACMSD, an enzyme involved in tryptophan metabolism and linked to various diseases. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the ACMSD protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in metabolism, neurobiology, and disease mechanisms.
ACMSD plays a crucial role in regulating the balance of kynurenine pathway metabolites, impacting immune responses, neuroinflammation, and neurodegenerative disorders. Its involvement in various diseases such as cancer, autoimmune conditions, and neurological disorders highlights its potential as a therapeutic target. By studying ACMSD activity, researchers can gain insights into disease mechanisms and potentially identify new treatment strategies targeting tryptophan metabolism pathways.
Product Name:
ACMSD Rabbit Polyclonal Antibody
SKU:
CAB15953
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_612199.2).
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
Purification Method:
Affinity purification
Gene ID:
130013
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ACMSD Rabbit pAb (CAB15953) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
