Anti-AFF4 Antibody (CAB4644)
- SKU:
- CAB4644
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AFF4
- AF5Q31
- CHOPS
- MCEF
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Product Name: | AFF4 Rabbit pAb |
| Product Code: | CAB4644 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AFF4, AF5Q31, CHOPS, MCEF |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human AFF4 (NP_055238.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, HeLa, 293T, LO2, MCF7, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human AFF4 (NP_055238.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNRE DRNV LRMK ERER RNQE IQQG EDAF PPSS PLFA EPYK VTSK EDKL SSRI QSML GNYD EMKD FIGD RSIP KLVA IPKP TVPP SADE KSNP NFFE QRHG GSHQ SSKW TPVG PAPS TSQS QKRS SGLQ SGHS SQRT SAGS SSGT NSSG QRHD RESY NNSG SSSR KKGQ HGSE HSKS RSSS PGKP QAVS SLNS SHSR SHGN DHHS KEHQ RSKS PRDP DANW |
| Gene ID: | 27125 |
| Uniprot: | Q9UHB7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 38kDa/98kDa/127kDa |
| Observed MW: | 150kDa |
| UniProt Protein Function: | MCEF: a putative transcription factor. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb). Genetic fusion of its gene with MLL has been observed in a subset of acute lymphoblastic leukemia patients. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 5q31 Cellular Component: nucleoplasm; transcription elongation factor complex; mitochondrion; nucleolus; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; spermatid development Disease: Chops Syndrome |
| NCBI Summary: | The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UHB7 |
| NCBI GenInfo Identifier: | 74720814 |
| NCBI Gene ID: | 27125 |
| NCBI Accession: | Q9UHB7.1 |
| UniProt Related Accession: | Q9UHB7 |
| Molecular Weight: | |
| NCBI Full Name: | AF4/FMR2 family member 4 |
| NCBI Synonym Full Names: | AF4/FMR2 family member 4 |
| NCBI Official Symbol: | AFF4Â Â |
| NCBI Official Synonym Symbols: | MCEF; CHOPS; AF5Q31Â Â |
| NCBI Protein Information: | AF4/FMR2 family member 4 |
| UniProt Protein Name: | AF4/FMR2 family member 4 |
| UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein |
| Protein Family: | AF4/FMR2 family |
| UniProt Gene Name: | AFF4Â Â |
| UniProt Entry Name: | AFF4_HUMAN |
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