The AAAS Antibody (CAB6427) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting Aladin in a variety of samples, making it ideal for use in Western blotting applications.Aladin plays a crucial role in regulating the transport of molecules between the nucleus and cytoplasm, making it essential for various cellular processes such as gene expression and protein synthesis. Dysregulation of Aladin has been implicated in diseases such as Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder (AAA syndrome), highlighting the importance of studying this protein in both normal and pathological conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
AAAS Antibody
SKU:
CAB6427
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method
Affinity purification
Gene ID
8086
RRID
AB_2767029
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using AAAS Rabbit pAb (CAB6427) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
