Description
AML1 (Phospho-Ser303)Transcription Factor Activity Assay
The AML1 (phospho-Ser303) Transcription Factor Activity Assay Kit is a powerful tool for studying the activity of the AML1 transcription factor in research settings. This assay kit is designed for the accurate detection and quantification of AML1 phosphorylated at serine 303, allowing researchers to monitor changes in AML1 activity in response to various stimuli.AML1 is a key transcription factor that plays a critical role in regulating gene expression involved in hematopoiesis and immune cell development. Phosphorylation of AML1 at serine 303 has been shown to impact its transcriptional activity, making this kit an invaluable resource for studying the regulation of gene expression in these processes.
With high sensitivity and specificity, the AML1 (phospho-Ser303) Transcription Factor Activity Assay Kit provides reliable and reproducible results, making it suitable for a wide range of research applications. Researchers studying hematopoiesis, immune cell development, and gene regulation will find this kit essential for their work.
| Product Name: | AML1 (Phospho-Ser303)Transcription Factor Activity Assay |
| Product Code: | TFAB00001 |
| Target: | AML1 (Phospho-Ser303) |
| Synonyms: | Transcriptional adapter 2-like, ADA2-like protein |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie AML1 (Phospho-Ser303) transcription factor activity assay allows for the detection and qualitative analysis of AML1 (Phospho-Ser303) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. |
| NCBI Summary: | Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009] |
| UniProt Code: | O75478 |
| NCBI GenInfo Identifier: | 317373498 |
| NCBI Gene ID: | 6871 |
| NCBI Accession: | O75478.3 |
| UniProt Secondary Accession: | O75478,Q9BVJ0, Q9UCW2, Q9UP49, A8MVD0, B3KMU9, |
| UniProt Related Accession: | O75478,AAB50689 |
| Molecular Weight: | 36,054 Da |
| NCBI Full Name: | Transcriptional adapter 2-alpha |
| NCBI Synonym Full Names: | transcriptional adaptor 2A |
| NCBI Official Symbol: | TADA2A |
| NCBI Official Synonym Symbols: | ADA2; ADA2A; KL04P; hADA2; TADA2L |
| NCBI Protein Information: | transcriptional adapter 2-alpha |
| UniProt Protein Name: | Transcriptional adapter 2-alpha |
| UniProt Synonym Protein Names: | Transcriptional adapter 2-like; ADA2-like protein |
| Protein Family: | Transcriptional adapter |
| UniProt Gene Name: | TADA2A |
| UniProt Entry Name: | TAD2A_HUMAN |
