Anti-Amyloid Beta 1-42 Oligomer Antibody [2F9]

Amyloid Beta 1-42 Oligomer Antibody [2F9]

Amyloid Beta 1-42 Oligomer Antibody [2F9] is a rabbit recombinant monoclonal antibody directed against Amyloid Beta 1-42 Oligomer, offered by Assay Genie for research applications. Reported applications include WB and ELISA. Reported reactivity: Human. Supplied as IgG, purified by Protein A.

Amyloid beta (Aβ) peptide, particularly the 1-42 isoform (Aβ1-42), plays a central role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated through proteolytic cleavage of the amyloid precursor protein (APP) and can self-assemble into a range of aggregated species, including oligomers, protofibrils, fibrils, and ultimately extracellular plaques. Among these, Aβ1-42 oligomers are increasingly recognized as the most neurotoxic species, contributing to synaptic dysfunction, neuroinflammation, and cognitive decline. This amyloid beta oligomer antibody has been validated for high specificity toward amyloid beta aggregates, distinguishing them from aggregated Tau and Alpha Synuclein proteins. This specificity is critical for accurately detecting early-stage, soluble aggregates that precede plaque formation and are believed to drive early neurodegenerative changes in AD. Tools that selectively recognize aggregated amyloid beta are essential for advancing both basic research and translational efforts in Alzheimer’s disease. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg, 12 µg. For research use only; not for diagnostic or therapeutic procedures.