Anti-ABHD5 Antibody (CAB8673)
- SKU:
- CAB8673
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CDS
- CGI58
- IECN2
- NCIE2
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Product Name: | ABHD5 Rabbit mAb |
| Product Code: | CAB8673 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CDS, CGI58, IECN2, NCIE2 |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ABHD5 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | HepG2, RD, Rat liver, Rat testis |
| Immunogen: | A synthesized peptide derived from human ABHD5 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 51099 |
| Uniprot: | Q8WTS1 |
| Cellular Location: | Cytoplasm, Lipid droplet |
| Calculated MW: | 45kDa |
| Observed MW: | 42kDa |
| UniProt Protein Function: | ABHD5: a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Colocalized with PLIN and ADFP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues, and Chanarin-Dorfman syndrome (CDS), a triglyceride storage disease with impaired long-chain fatty acid oxidation and icthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.3.1.51; Lipase Chromosomal Location of Human Ortholog: 3p21 Cellular Component: intracellular membrane-bound organelle; cytoplasm; lipid particle; nucleus; cytosol Molecular Function:triacylglycerol lipase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophosphatidic acid acyltransferase activity Biological Process: triacylglycerol catabolic process; phosphatidic acid biosynthetic process; positive regulation of lipoprotein lipase activity; fatty acid metabolic process; cell differentiation Disease: Chanarin-dorfman Syndrome |
| NCBI Summary: | The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WTS1 |
| NCBI GenInfo Identifier: | 73921640 |
| NCBI Gene ID: | 51099 |
| NCBI Accession: | Q8WTS1.1 |
| UniProt Secondary Accession: | Q8WTS1,Q9Y369, B2R9K0, |
| UniProt Related Accession: | Q8WTS1 |
| Molecular Weight: | |
| NCBI Full Name: | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 |
| NCBI Synonym Full Names: | abhydrolase domain containing 5 |
| NCBI Official Symbol: | ABHD5Â Â |
| NCBI Official Synonym Symbols: | CDS; CGI58; IECN2; NCIE2Â Â |
| NCBI Protein Information: | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; lipid droplet-binding protein CGI-58; abhydrolase domain-containing protein 5 |
| UniProt Protein Name: | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 |
| UniProt Synonym Protein Names: | Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58 |
| Protein Family: | 1-acylglycerol-3-phosphate O-acyltransferase |
| UniProt Gene Name: | ABHD5Â Â |
| UniProt Entry Name: | ABHD5_HUMAN |
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