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Anti-AHCY Antibody (CAB2756)

SKU:
CAB2756
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AHCY
SAHH
adoHcyase
adenosylhomocysteinase
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

Product Name:AHCY Rabbit mAb
Product Code:CAB2756
Size:20uL, 50uL, 100uL
Synonyms:AHCY, SAHH, adoHcyase, adenosylhomocysteinase
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human AHCY.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, HepG2, A375, K-562, Mouse pancreas, Mouse liver, Mouse kidney, Rat kidney
Immunogen:A synthesized peptide derived from human AHCY.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:191
Uniprot:P23526
Cellular Location:Cytoplasm, Melanosome
Calculated MW:47kDa
Observed MW:45KDa
UniProt Protein Function:SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.
UniProt Protein Details:

Protein type:Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: neuron projection; cytoplasm; melanosome; cytosol; nucleus

Molecular Function:identical protein binding; adenyl nucleotide binding; adenosylhomocysteinase activity

Biological Process: methylation; circadian sleep/wake cycle; S-adenosylmethionine cycle; sulfur amino acid metabolic process; xenobiotic metabolic process; response to hypoxia; S-adenosylhomocysteine catabolic process; one-carbon compound metabolic process; chronic inflammatory response to antigenic stimulus; response to nutrient

Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency

NCBI Summary:S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Code:P23526
NCBI GenInfo Identifier:20141702
NCBI Gene ID:191
NCBI Accession:P23526.4
UniProt Secondary Accession:P23526,Q96A36, A8K307, B3KUN3, E1P5P2, F5H737,
UniProt Related Accession:P23526
Molecular Weight:432
NCBI Full Name:Adenosylhomocysteinase
NCBI Synonym Full Names:adenosylhomocysteinase
NCBI Official Symbol:AHCY  
NCBI Official Synonym Symbols:SAHH; adoHcyase  
NCBI Protein Information:adenosylhomocysteinase; S-adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase
UniProt Protein Name:Adenosylhomocysteinase
UniProt Synonym Protein Names:S-adenosyl-L-homocysteine hydrolase
Protein Family:Adenosylhomocysteinase
UniProt Gene Name:AHCY  
UniProt Entry Name:SAHH_HUMAN

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