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Anti-ALOX5 Antibody (CAB2877)

SKU:
CAB2877
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
5-LO
5-LOX
5LPG
LOG5
Research Area:
Metabolism
$167 - $503
Frequently bought together:

Description

Product Name:ALOX5 Rabbit mAb
Product Code:CAB2877
Size:20uL, 50uL, 100uL
Synonyms:5-LO, 5-LOX, 5LPG, LOG5
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ALOX5
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, Rat lung
Immunogen:A synthesized peptide derived from human ALOX5
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:240
Uniprot:P09917
Calculated MW:78kDa
Observed MW:78kDa
UniProt Protein Function:5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.
UniProt Protein Details:

Protein type:Lipid Metabolism - linoleic acid; Nuclear envelope; EC 1.13.11.34; Oxidoreductase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol

Molecular Function:protein binding; iron ion binding; arachidonate 5-lipoxygenase activity

Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process

Disease: Asthma, Susceptibility To

NCBI Summary:This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:P09917
NCBI GenInfo Identifier:126407
NCBI Gene ID:240
NCBI Accession:P09917.2
UniProt Secondary Accession:P09917,Q5JQ14, B7ZLS0, E5FPY5, E5FPY7, E5FPY8,
UniProt Related Accession:P09917
Molecular Weight:674
NCBI Full Name:Arachidonate 5-lipoxygenase
NCBI Synonym Full Names:arachidonate 5-lipoxygenase
NCBI Official Symbol:ALOX5  
NCBI Official Synonym Symbols:5-LO; 5LPG; LOG5; 5-LOX  
NCBI Protein Information:arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform
UniProt Protein Name:Arachidonate 5-lipoxygenase
Protein Family:Arachidonate 5-lipoxygenase
UniProt Gene Name:ALOX5  
UniProt Entry Name:LOX5_HUMAN

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