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Anti-ATP1A2 Antibody (CAB19278)

SKU:
CAB19278
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATP1A2
FHM2
MHP2
ATPase Na+/K+ transporting subunit alpha 2
€139 - €419
Frequently bought together:

Description

Product Name:ATP1A2 Rabbit mAb
Product Code:CAB19278
Size:20uL, 50uL, 100uL
Synonyms:ATP1A2, FHM2, MHP2, ATPase Na+/K+ transporting subunit alpha 2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ATP1A2.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart, Mouse skeletal muscle, Rat heart
Immunogen:Recombinant protein of human ATP1A2.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:477
Uniprot:P50993
Cellular Location:Cell membrane, Membrane, Multi-pass membrane protein
Calculated MW:102kDa
Observed MW:100KDa
UniProt Protein Function:ATP1A2: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. Defects in ATP1A2 are the cause of familial hemiplegic migraine type 2 (FHM2). FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. Defects in ATP1A2 are a cause of alternating hemiplegia of childhood 1 (AHC1). AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
UniProt Protein Details:

Protein type:Transporter; Membrane protein, integral; Hydrolase; EC 3.6.3.9; Transporter, ion channel; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: caveola; cytoplasm; cytosol; dendritic spine; endosome; intracellular membrane-bound organelle; membrane; myelin sheath; plasma membrane; sodium:potassium-exchanging ATPase complex; T-tubule

Molecular Function:ATP binding; ATPase activity; chaperone binding; drug binding; potassium ion binding; protein binding; sodium ion binding; sodium:potassium-exchanging ATPase activity

Biological Process: adult locomotory behavior; ATP hydrolysis coupled proton transport; ATP metabolic process; cardiac muscle contraction; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; locomotion; negative regulation of heart contraction; negative regulation of striated muscle contraction; neurological control of breathing; neurotransmitter uptake; potassium ion import; potassium ion transport; reduction of cytosolic calcium ion concentration; regulation of blood pressure; regulation of glutamate uptake during transmission of nerve impulse; regulation of smooth muscle contraction; regulation of striated muscle contraction; regulation of synaptic transmission, glutamatergic; regulation of the force of heart contraction; regulation of vasoconstriction; response to nicotine; sodium ion transport; transmembrane transport; visual learning

Disease: Alternating Hemiplegia Of Childhood 1; Migraine, Familial Hemiplegic, 2

NCBI Summary:The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
UniProt Code:P50993
NCBI GenInfo Identifier:1703467
NCBI Gene ID:477
NCBI Accession:P50993.1
UniProt Secondary Accession:P50993,Q07059, Q5JW74, Q86UZ5, Q9UQ25, D3DVE4,
UniProt Related Accession:P50993
Molecular Weight:112,265 Da
NCBI Full Name:Sodium/potassium-transporting ATPase subunit alpha-2
NCBI Synonym Full Names:ATPase Na+/K+ transporting subunit alpha 2
NCBI Official Symbol:ATP1A2  
NCBI Official Synonym Symbols:FHM2; MHP2  
NCBI Protein Information:sodium/potassium-transporting ATPase subunit alpha-2
UniProt Protein Name:Sodium/potassium-transporting ATPase subunit alpha-2
UniProt Synonym Protein Names:Sodium pump subunit alpha-2
Protein Family:Sodium/potassium-transporting ATPase
UniProt Gene Name:ATP1A2  
UniProt Entry Name:AT1A2_HUMAN

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