Anti-ClfA Antibody (AZD7745) is a research-grade biosimilar monoclonal antibody targeting Clumping factor A. It is a human IgG antibody. Reactivity: Staphylococcus aureus. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Clumping factor A (ClfA) is a ~97 kDa protein. Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis.
Product Name:
Anti-ClfA Antibody (AZD7745)
SKU:
GXBS02633
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
AZD7745
Target:
Clumping factor A
Isotype:
IgG
Host Species:
Human
Reactivity:
Staphylococcus aureus
Applications:
ELISA, Functional assay, Research in vivo
Synonyms:
SAR114
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
