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Anti-eEF2 Antibody (CAB9721)

SKU:
CAB9721
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EEF-2
EF-2
EF2
SCA26
Research Area:
Metabolism
$167 - $503
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Description

Product Name:eEF2 Rabbit mAb
Product Code:CAB9721
Size:20uL, 50uL, 100uL
Synonyms:EEF-2, EF-2, EF2, SCA26
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human eEF2
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, NIH/3T3, Jurkat, Mouse liver, Rat spleen
Immunogen:A synthesized peptide derived from human eEF2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1938
Uniprot:P13639
Cellular Location:Cytoplasm, Nucleus
Calculated MW:95kDa
Observed MW:100kDa
UniProt Protein Function:EEF2: a member of the GTP-binding translation elongation factor family. An essential factor for protein synthesis. Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by eEF2 kinase phosphorylation. eEF2 kinase is normally dependent on Ca2+ ions and calmodulin. eEF2 kinase can also be activated by PKA in response to elevated cAMP levels, which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation.
UniProt Protein Details:

Protein type:Translation elongation; Translation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: polysome; membrane; cytoplasm; plasma membrane; cytosol; ribonucleoprotein complex; nucleus

Molecular Function:GTPase activity; protein binding; GTP binding; protein kinase binding; translation elongation factor activity

Biological Process: translational elongation; cellular protein metabolic process; translation; positive regulation of translation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; pathogenesis; hemopoietic progenitor cell differentiation; gene expression; post-translational protein modification

Disease: Spinocerebellar Ataxia 26

NCBI Summary:This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
UniProt Code:P13639
NCBI GenInfo Identifier:119172
NCBI Gene ID:1938
NCBI Accession:P13639.4
UniProt Secondary Accession:P13639,Q58J86, B2RMP5, D6W618,
UniProt Related Accession:P13639
Molecular Weight:858
NCBI Full Name:Elongation factor 2
NCBI Synonym Full Names:eukaryotic translation elongation factor 2
NCBI Official Symbol:EEF2  
NCBI Official Synonym Symbols:EF2; EF-2; EEF-2; SCA26  
NCBI Protein Information:elongation factor 2; polypeptidyl-tRNA translocase
UniProt Protein Name:Elongation factor 2
Protein Family:Elongation factor
UniProt Gene Name:EEF2  
UniProt Entry Name:EF2_HUMAN

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