Anti-ERAP1 Antibody (CAB5978)
- SKU:
- CAB5978
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- A-LAP
- ALAP
- APPILS
- ARTS-1
- ARTS1
- ERAAP
- ERAAP1
- PILS-AP
- PILSAP
- Research Area:
- Immunology
Frequently bought together:
Description
| Product Name: | ERAP1 Rabbit mAb |
| Product Code: | CAB5978 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ERAP1 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Jurkat, Mouse lung, Mouse liver, Rat liver |
| Immunogen: | A synthesized peptide derived from human ERAP1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 51752 |
| Uniprot: | Q9NZ08 |
| Calculated MW: | 100kDa |
| Observed MW: | 108KDa |
| UniProt Protein Function: | ARTS1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.11.-; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q15 Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; membrane; plasma membrane Molecular Function:aminopeptidase activity; endopeptidase activity; interleukin-1, Type II receptor binding; interleukin-6 receptor binding; metalloexopeptidase activity; peptide binding; protein binding; zinc ion binding Biological Process: angiogenesis; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; membrane protein ectodomain proteolysis; peptide catabolic process; regulation of blood pressure |
| NCBI Summary: | The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] |
| UniProt Code: | Q9NZ08 |
| NCBI GenInfo Identifier: | 158937334 |
| NCBI Gene ID: | 51752 |
| NCBI Accession: | Q9NZ08.3 |
| UniProt Secondary Accession: | Q9NZ08,O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2 |
| UniProt Related Accession: | Q9NZ08 |
| Molecular Weight: | 107,841 Da |
| NCBI Full Name: | Endoplasmic reticulum aminopeptidase 1 |
| NCBI Synonym Full Names: | endoplasmic reticulum aminopeptidase 1 |
| NCBI Official Symbol: | ERAP1Â Â |
| NCBI Official Synonym Symbols: | ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-APÂ Â |
| NCBI Protein Information: | endoplasmic reticulum aminopeptidase 1 |
| UniProt Protein Name: | Endoplasmic reticulum aminopeptidase 1 |
| UniProt Synonym Protein Names: | ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| Protein Family: | Endoplasmic reticulum aminopeptidase |
| UniProt Gene Name: | ERAP1Â Â |
| UniProt Entry Name: | ERAP1_HUMAN |
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