Anti-FADD Antibody (CAB20252)
- SKU:
- CAB20252
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- Mort1/F
- Mort1/FADD
Description
| Product Name: | FADD Rabbit pAb |
| Product Code: | CAB20252 |
| Size: | 50uL, 100uL |
| Synonyms: | Mort1/F, Mort1/FADD |
| Applications: | WB, IF, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human FADD. |
| Applications: | WB, IF, IP |
| Recommended Dilutions: | WB 1:200 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, Mouse heart |
| Immunogen: | Recombinant protein of human FADD. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 14082 |
| Uniprot: | Q61160 |
| Observed MW: | 28KDa |
| UniProt Protein Function: | FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Apoptosis Cellular Component: CD95 death-inducing signaling complex; cytoplasm; cytosol; lipid raft; neuron projection; plasma membrane; protein complex Molecular Function:death receptor binding; identical protein binding; protease binding; protein binding; protein complex binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding Biological Process: apoptosis; cardiac muscle development; defense response to virus; innate immune response; lymph node development; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; protein heterooligomerization; spleen development; T cell differentiation; T cell differentiation in the thymus; T cell homeostasis; thymus development |
| UniProt Code: | Q61160 |
| NCBI GenInfo Identifier: | 2498356 |
| NCBI Gene ID: | 14082 |
| NCBI Accession: | Q61160.1 |
| UniProt Secondary Accession: | Q61160,Q3TC37, Q61082, |
| UniProt Related Accession: | Q61160 |
| Molecular Weight: | 22,960 Da |
| NCBI Full Name: | FAS-associated death domain protein |
| NCBI Synonym Full Names: | Fas (TNFRSF6)-associated via death domain |
| NCBI Official Symbol: | Fadd  |
| NCBI Official Synonym Symbols: | Mort1/FADDÂ Â |
| NCBI Protein Information: | FAS-associated death domain protein |
| UniProt Protein Name: | FAS-associated death domain protein |
| UniProt Synonym Protein Names: | FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Protein FADD |
| Protein Family: | Fas-associated death domain protein |
| UniProt Gene Name: | Fadd  |
| UniProt Entry Name: | FADD_MOUSE |
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