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Anti-Histone H1.4 Antibody (CAB20550)

SKU:
CAB20550
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
H1E
H1.4
H1F4
RMNS
H1s-4
HIST1H1E
dJ221C16.5
€139 - €419
Frequently bought together:

Description

Product Name:Histone H1.4 Rabbit pAb
Product Code:CAB20550
Size:50uL, 100uL
Synonyms:H1E, H1.4, H1F4, RMNS, H1s-4, HIST1H1E, dJ221C16.5
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human Histone H1.4.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:Recombinant protein of human Histone H1.4.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3008
Uniprot:P10412
Calculated MW:21kDa
Observed MW:30KDa
UniProt Protein Function:H1E: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nuclear heterochromatin; nucleus

Molecular Function:chromatin DNA binding; protein binding

NCBI Summary:Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
UniProt Code:P10412
NCBI GenInfo Identifier:121919
NCBI Gene ID:3008
NCBI Accession:P10412.2
UniProt Secondary Accession:P10412,Q4VB25,
UniProt Related Accession:P10412
Molecular Weight:21,865 Da
NCBI Full Name:Histone H1.4
NCBI Synonym Full Names:histone cluster 1, H1e
NCBI Official Symbol:HIST1H1E  
NCBI Official Synonym Symbols:H1E; H1.4; H1F4; H1s-4; dJ221C16.5  
NCBI Protein Information:histone H1.4
UniProt Protein Name:Histone H1.4
UniProt Synonym Protein Names:Histone H1b; Histone H1s-4
Protein Family:Histone
UniProt Gene Name:HIST1H1E  
UniProt Entry Name:H14_HUMAN

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