Anti-Histone H2A Antibody (CAB3692)

Product Name:	Histone H2A Rabbit mAb
Product Code:	CAB3692
Size:	20uL, 50uL, 100uL
Synonyms:	H2A.1, H2A.2, H2A/a, H2AFA
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat, Other (Wide Range)
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human Histone H2A

Applications:	WB, IHC
Recommended Dilutions:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat, Other (Wide Range)
Positive Samples:	HeLa, HepG2, Jurkat, Mouse spleen, Mouse thymus, Rat liver

Immunogen:	A synthesized peptide derived from human Histone H2A
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	3012
Uniprot:	P04908
Cellular Location:	Chromosome, Nucleus
Calculated MW:	14kDa
Observed MW:	14kDa

UniProt Protein Function:	HIST1H2AE: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p22.2 Cellular Component: nuclear chromatin; nucleus Molecular Function:DNA binding Biological Process: chromatin silencing; negative regulation of cell proliferation
NCBI Summary:	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Code:	P04908
NCBI GenInfo Identifier:	124028530
NCBI Gene ID:	3012
NCBI Accession:	P04908.2
UniProt Secondary Accession:	P04908,P28001, Q76P63,
UniProt Related Accession:	P04908
Molecular Weight:	14kDa
NCBI Full Name:	Histone H2A type 1-B/E
NCBI Synonym Full Names:	histone cluster 1 H2A family member e
NCBI Official Symbol:	HIST1H2AE
NCBI Official Synonym Symbols:	H2A.1; H2A.2; H2A/a; H2AFA
NCBI Protein Information:	histone H2A type 1-B/E
UniProt Protein Name:	Histone H2A type 1-B/E
UniProt Synonym Protein Names:	Histone H2A.2; Histone H2A/a; Histone H2A/m
UniProt Gene Name:	HIST1H2AB