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Anti-HRH1 Antibody (CAB20159)

SKU:
CAB20159
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
H1R
H1-R
HH1R
hisH1
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

Product Name:HRH1 Rabbit pAb
Product Code:CAB20159
Size:50uL, 100uL
Synonyms:H1R, H1-R, HH1R, hisH1
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human HRH1.
Applications:WB, IF
Recommended Dilutions:WB 1:1000 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, Mouse liver, Rat liver
Immunogen:Recombinant protein of human HRH1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3269
Uniprot:P35367
Calculated MW:56kDa
Observed MW:60KDa
UniProt Protein Function:H1R: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: nucleoplasm; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function:G-protein coupled receptor activity; histamine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; positive regulation of vasoconstriction; eosinophil chemotaxis; visual learning; regulation of synaptic plasticity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of inositol trisphosphate biosynthetic process; regulation of vascular permeability; inflammatory response; memory

NCBI Summary:Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
UniProt Code:P35367
NCBI GenInfo Identifier:547645
NCBI Gene ID:3269
NCBI Accession:P35367.1
UniProt Secondary Accession:P35367,Q6P9E5, A8K047,
UniProt Related Accession:P35367
Molecular Weight:487
NCBI Full Name:Histamine H1 receptor
NCBI Synonym Full Names:histamine receptor H1
NCBI Official Symbol:HRH1  
NCBI Official Synonym Symbols:H1R; H1-R; HH1R; hisH1  
NCBI Protein Information:histamine H1 receptor; histamine receptor, subclass H1
UniProt Protein Name:Histamine H1 receptor
Protein Family:Histamine H1 receptor
UniProt Gene Name:HRH1  
UniProt Entry Name:HRH1_HUMAN

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