Anti-Human B2M/Beta-2-microglobulin Recombinant Nanobody (SAA2322) is a recombinant nanobody targeting Human B2M/Beta-2-microglobulin (clone SAA2322). Format: VHH-Fc (alpaca host). Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA. Purity: >95% as determined by SDS-PAGE. For research use only.
Beta-2-microglobulin (B2M/β2M) is a ~13 kDa protein. Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.