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[KO Validated] IκBα Rabbit Polyclonal Antibody (CAB11168)

SKU:
CAB11168
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • KO Validated Antibodies 1 Anti-IkBAlpha Antibody CAB11168KO Validated
  • KO Validated Antibodies 1 Anti-IkBAlpha Antibody CAB11168KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] IκBα Rabbit Polyclonal Antibody
SKU:CAB11168
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκBα (NP_065390.1).
Sequence:MFQA AERP QEWA MEGP RDGL KKER LLDD RHDS GLDS MKDE EYEQ MVKE LQEI RLEP QEVP RGSE PWKQ QLTE DGDS FLHL AIIH EEKA LTME VIRQ VKGD LAFL NFQN NLQQ TPLH LAVI TNQP EIAE ALLG AGCD PELR DFRG NTPL HLAC EQGC LASV GVLT QSCT TPHL HSIL KATN YNGH TCLH LASI HGYL GIVE LLVS LGAD VNAQ EPCN GRTA LHLA VDLQ NPDL VSLL LKCG ADVN RVTY QGYS PYQL TWGR PSTR IQQQ LGQL TLEN LQML PESE DEES YDTE SEFT EFTE DELP YDDC VFGG QRLT L
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:IKBA; MAD-3; NFKBI; EDAID2; IκBα
Positive Sample:Mouse thymus,Rat thymus
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:36kDa
Observed MW:36kDa

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Purification Method:Affinity purification
Gene ID:4792
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using IκBα antibody (CAB11168) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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