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Anti-MBD2 Antibody (CAB4032)

SKU:
CAB4032
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DMTase
NY-CO-41
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

Product Name:MBD2 Rabbit mAb
Product Code:CAB4032
Size:20uL, 50uL, 100uL
Synonyms:DMTase, NY-CO-41
Applications:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MBD2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:A synthesized peptide derived from human MBD2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8932
Uniprot:Q9UBB5
Calculated MW:29, 43kDa
Observed MW:46KDa
UniProt Protein Function:MBD2: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. May enhance the activation of some unmethylated cAMP-responsive promoters. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: nucleoplasm; heterochromatin; protein complex; cytoplasm; nuclear chromatin; histone deacetylase complex; nucleus

Molecular Function:mRNA binding; protein domain specific binding; protein binding; nucleosomal DNA binding; siRNA binding; methyl-CpG binding; satellite DNA binding

Biological Process: cellular protein complex assembly; transcription, DNA-dependent; maternal behavior; negative regulation of gene expression, epigenetic; ATP-dependent chromatin remodeling; gene expression; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; regulation of gene expression, epigenetic; regulation of cell proliferation

NCBI Summary:DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
UniProt Code:Q9UBB5
NCBI GenInfo Identifier:50401198
NCBI Gene ID:8932
NCBI Accession:Q9UBB5.1
UniProt Related Accession:Q9UBB5
Molecular Weight:56kDa; 62kDa
NCBI Full Name:Methyl-CpG-binding domain protein 2
NCBI Synonym Full Names:methyl-CpG binding domain protein 2
NCBI Official Symbol:MBD2  
NCBI Official Synonym Symbols:DMTase; NY-CO-41  
NCBI Protein Information:methyl-CpG-binding domain protein 2
UniProt Protein Name:Methyl-CpG-binding domain protein 2
UniProt Synonym Protein Names:Demethylase; DMTase; Methyl-CpG-binding protein MBD2
Protein Family:Methyl-CpG-binding domain protein
UniProt Gene Name:MBD2  
UniProt Entry Name:MBD2_HUMAN

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