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Anti-MED4 Antibody (CAB0623)

SKU:
CAB0623
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MED4
ARC36
DRIP36
HSPC126
TRAP36
VDRIP
mediator complex subunit 4
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

Product Name:MED4 Rabbit mAb
Product Code:CAB0623
Size:20uL, 50uL, 100uL
Synonyms:MED4, ARC36, DRIP36, HSPC126, TRAP36, VDRIP, mediator complex subunit 4
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MED4.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:TE-1, Jurkat, U-87MG, Mouse lung, Rat liver
Immunogen:A synthesized peptide derived from human MED4.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:29079
Uniprot:Q9NPJ6
Cellular Location:Nucleus
Calculated MW:35kDa
Observed MW:36KDa
UniProt Protein Function:MED4: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 4 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: nucleoplasm; membrane; Srb-mediator complex; nucleus

Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription cofactor activity; receptor activity; thyroid hormone receptor binding

Biological Process: steroid hormone receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; gene expression

NCBI Summary:This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Code:Q9NPJ6
NCBI GenInfo Identifier:29840770
NCBI Gene ID:29079
NCBI Accession:Q9NPJ6.1
UniProt Secondary Accession:Q9NPJ6,Q53GB4, Q53H68, Q5T912, Q6FHC4, Q6IA79, Q9BS95 Q9NYR5, B4DX67,
UniProt Related Accession:Q9NPJ6
Molecular Weight:24,947 Da
NCBI Full Name:Mediator of RNA polymerase II transcription subunit 4
NCBI Synonym Full Names:mediator complex subunit 4
NCBI Official Symbol:MED4  
NCBI Official Synonym Symbols:ARC36; VDRIP; DRIP36; TRAP36; HSPC126  
NCBI Protein Information:mediator of RNA polymerase II transcription subunit 4; TRAP/SMCC/PC2 subunit p36; mediator, 34-kD subunit, homolog; activator-recruited cofactor 36 kDa component; vitamin D receptor-interacting protein, 36-kD; vitamin D3 receptor-interacting protein complex 36 kDa component
UniProt Protein Name:Mediator of RNA polymerase II transcription subunit 4
UniProt Synonym Protein Names:Activator-recruited cofactor 36 kDa component; ARC36; Mediator complex subunit 4; TRAP/SMCC/PC2 subunit p36 subunit; Vitamin D3 receptor-interacting protein complex 36 kDa component; DRIP36
Protein Family:Mediator of RNA polymerase II transcription
UniProt Gene Name:MED4  
UniProt Entry Name:MED4_HUMAN

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