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Anti-PGC1alpha Antibody (CAB20995)

SKU:
CAB20995
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
€179 - €469
Frequently bought together:

Description

Antibody Name:Anti-PGC1alpha Antibody (CAB20995)
Antibody SKU:CAB20995
Antibody Size:50µL, 100µL
Application:Western blotting, Immunohistochemistry
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-480 of human PGC1α (NP_037393.1).
Application:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:500 - 1:2000
IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse kidney, Rat kidney, Rat stomach
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-480 of human PGC1α (NP_037393.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QGNN STKK GPEQ SELY AQLS KSSV LTGG HEER KTKR PSLR LFGD HDYC QSIN SKTE ILIN ISQE LQDS RQLE NKDV SSDW QGQI CSST DSDQ CYLR ETLE ASKQ VSPC STRK QLQD QEIR AELN KHFG HPSQ AVFD DEAD K
Cellular Location:Cytoplasm, Nucleus, PML body
Calculated MW:14kDa/30kDa/31kDa/33kDa/77kDa/89kDa/91kDa
Observed MW:100KDa
Synonyms:PPARGC1A, LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1, PPARG coactivator 1 alpha, PGC1 alpha
Background:The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Western blot analysis of extracts of various cell lines, using PGC1α antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.Western blot analysis of extracts of various cell lines, using PGC1α antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

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