Anti-Phospho-MCM2-S139 Antibody (CABP1192)

Product Name:	Phospho-MCM2-S139 Rabbit pAb
Product Code:	CABP1192
Size:	50uL, 100uL
Synonyms:	MCM2, BM28, CCNL1, CDCL1, D3S3194, DFNA70, MITOTIN, cdc19
Applications:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthetic phosphorylated peptide around S139 of human MCM2.

Applications:	WB
Recommended Dilutions:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	HeLa

Immunogen:	A synthetic phosphorylated peptide around S139 of human MCM2.
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	4171
Uniprot:	P49736
Cellular Location:	Nucleus
Calculated MW:	101kDa
Observed MW:	125KDa

UniProt Protein Function:	MCM2: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.
UniProt Protein Details:	Protein type:DNA-binding; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 3q21 Cellular Component: microtubule cytoskeleton; nucleoplasm; MCM complex; cytoplasm; nuclear origin of replication recognition complex; nucleus; chromatin Molecular Function:protein binding; DNA helicase activity; DNA binding; histone binding; metal ion binding; DNA replication origin binding; ATP binding Biological Process: DNA unwinding during replication; nucleosome assembly; DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; cell cycle; DNA replication; G1/S transition of mitotic cell cycle
NCBI Summary:	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
UniProt Code:	P49736
NCBI GenInfo Identifier:	41019490
NCBI Gene ID:	4171
NCBI Accession:	P49736.4
UniProt Secondary Accession:	P49736,Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7
UniProt Related Accession:	P49736
Molecular Weight:	904
NCBI Full Name:	DNA replication licensing factor MCM2
NCBI Synonym Full Names:	minichromosome maintenance complex component 2
NCBI Official Symbol:	MCM2
NCBI Official Synonym Symbols:	BM28; CCNL1; CDCL1; cdc19; D3S3194; MITOTIN
NCBI Protein Information:	DNA replication licensing factor MCM2; cyclin-like 1; nuclear protein BM28; cell devision cycle-like 1; minichromosome maintenance protein 2 homolog; minichromosome maintenance deficient 2 (mitotin); MCM2 minichromosome maintenance deficient 2, mitotin
UniProt Protein Name:	DNA replication licensing factor MCM2
UniProt Synonym Protein Names:	Minichromosome maintenance protein 2 homolog; Nuclear protein BM28
Protein Family:	DNA replication licensing factor
UniProt Gene Name:	MCM2
UniProt Entry Name:	MCM2_HUMAN