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Anti-Phospho-PAK1/2/3-S144/S141/S139 Antibody (CABP1158)

SKU:
CABP1158
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PAKalpha
Research Area:
Cell Death
€329 - €419
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Description

Product Name:Phospho-PAK1/2/3-S144/S141/S139 Rabbit mAb
Product Code:CABP1158
Size:20uL, 50uL, 100uL
Synonyms:PAKalpha
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S144 of human PAK1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding S144 of human PAK1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5058/5062/5063
Uniprot:Q13153/Q13177/O75914
Calculated MW:65kDa
Observed MW:65kDa
UniProt Protein Function:PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKA subfamily

Chromosomal Location of Human Ortholog: 11q13-q14

Cellular Component: axon; cytoplasm; cytosol; dendrite; filamentous actin; focal adhesion; Golgi apparatus; growth cone; intercellular junction; nuclear membrane; plasma membrane; protein complex; ruffle; Z disc

Molecular Function:ATP binding; collagen binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; Rac GTPase binding

Biological Process: actin cytoskeleton reorganization; activation of protein kinase activity; amygdala development; apoptosis; axon guidance; branching morphogenesis of a tube; cell migration; cellular response to insulin stimulus; ephrin receptor signaling pathway; exocytosis; innate immune response; MAPKKK cascade; neurite morphogenesis; neuromuscular junction development; positive regulation of cell migration; positive regulation of estrogen receptor signaling pathway; positive regulation of JNK activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; protein amino acid autophosphorylation; protein amino acid phosphorylation; receptor clustering; regulation of apoptosis; regulation of gene expression; regulation of mitotic cell cycle; response to hypoxia; Rho protein signal transduction; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated protein kinase signaling pathway; T cell costimulation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; wound healing

NCBI Summary:This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
UniProt Code:Q13153
NCBI GenInfo Identifier:90111767
NCBI Gene ID:5058
NCBI Accession:Q13153.2
UniProt Secondary Accession:Q13153,O75561, Q13567, Q32M53, Q32M54, Q86W79,
UniProt Related Accession:Q13153
Molecular Weight:
NCBI Full Name:Serine/threonine-protein kinase PAK 1
NCBI Synonym Full Names:p21 protein (Cdc42/Rac)-activated kinase 1
NCBI Official Symbol:PAK1  
NCBI Official Synonym Symbols:PAKalpha  
NCBI Protein Information:serine/threonine-protein kinase PAK 1
UniProt Protein Name:Serine/threonine-protein kinase PAK 1
UniProt Synonym Protein Names:Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:PAK1  
UniProt Entry Name:PAK1_HUMAN

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