Anti-RhoA [KO Validated] Antibody (CAB18695)
- SKU:
- CAB18695
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ARHA
- ARH12
- RHO12
- EDFAOB
- RHOH12
- Research Area:
- Cell Cycle
Description
| Product Name: | [KO Validated] RhoA Rabbit pAb |
| Product Code: | CAB18695 |
| Size: | 20uL |
| Synonyms: | ARHA, ARH12, RHO12, EDFAOB, RHOH12 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human RhoA. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, NIH/3T3, U-251MG, HUVEC, Mouse brain |
| Immunogen: | Recombinant protein of human RhoA. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 387 |
| Uniprot: | P61586 |
| Cellular Location: | Cell membrane, Cell projection, Cleavage furrow, Cytoplasm, Cytoplasmic side, Lipid-anchor, Midbody, cell cortex, cytoskeleton, lamellipodium |
| Calculated MW: | 21kDa |
| Observed MW: | 21kDa |
| UniProt Protein Function: | RHOA: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. |
| UniProt Protein Details: | Protein type:G protein, monomeric, Rho; G protein, monomeric; Motility/polarity/chemotaxis; Oncoprotein; G protein Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: apical junction complex; focal adhesion; cytoskeleton; lamellipodium; plasma membrane; cell cortex; midbody; cytosol; cell junction; cleavage furrow Molecular Function:GTPase activity; protein binding; myosin binding; GTP binding Biological Process: axon guidance; nerve growth factor receptor signaling pathway; viral reproduction; metabolic process; negative chemotaxis; positive regulation of NF-kappaB import into nucleus; regulation of axonogenesis; regulation of cell migration; Rho protein signal transduction; regulation of osteoblast proliferation; substantia nigra development; transforming growth factor beta receptor signaling pathway; small GTPase mediated signal transduction; positive regulation of stress fiber formation; ephrin receptor signaling pathway; negative regulation of axonogenesis; positive regulation of cytokinesis; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; phosphoinositide-mediated signaling; apical junction assembly; regulation of small GTPase mediated signal transduction; positive regulation of axonogenesis; actin cytoskeleton organization and biogenesis; positive regulation of neuron differentiation; vascular endothelial growth factor receptor signaling pathway; blood coagulation |
| NCBI Summary: | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P61586 |
| NCBI GenInfo Identifier: | 47606458 |
| NCBI Gene ID: | 387 |
| NCBI Accession: | P61586.1 |
| UniProt Related Accession: | P61586 |
| Molecular Weight: | 22kDa |
| NCBI Full Name: | Transforming protein RhoA |
| NCBI Synonym Full Names: | ras homolog family member A |
| NCBI Official Symbol: | RHOAÂ Â |
| NCBI Official Synonym Symbols: | ARHA; ARH12; RHO12; RHOH12Â Â |
| NCBI Protein Information: | transforming protein RhoA |
| UniProt Protein Name: | Transforming protein RhoA |
| UniProt Synonym Protein Names: | Rho cDNA clone 12; h12 |
| Protein Family: | Rhotekin |
| UniProt Gene Name: | RHOAÂ Â |
| UniProt Entry Name: | RHOA_HUMAN |
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