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Anti-TACC3 Antibody (CAB19617)

SKU:
CAB19617
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ERIC-1
ERIC1
$167 - $503
Frequently bought together:

Description

Product Name:TACC3 Rabbit mAb
Product Code:CAB19617
Size:20uL, 50uL, 100uL
Synonyms:ERIC-1, ERIC1
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TACC3
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:A synthesized peptide derived from human TACC3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10460
Uniprot:Q9Y6A5
Calculated MW:140kDa
Observed MW:140KDa
UniProt Protein Function:TACC3: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May be involved in the control of cell growth and differentiation. May contribute to cancer. Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2. Interacts with GCN5L2 and PCAF. Up-regulated in various cancer cell lines. Belongs to the TACC family.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: centrosome; cytoplasm

Molecular Function:protein domain specific binding; protein binding

Biological Process: regulation of microtubule-based process; cell proliferation; cytoplasmic sequestering of transcription factor; astral microtubule organization and biogenesis; neurogenesis; regulation of cell cycle; response to hypoxia; hemopoiesis; microtubule cytoskeleton organization and biogenesis; cerebral cortex development; interkinetic nuclear migration

Disease: Bladder Cancer

NCBI Summary:The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. [provided by RefSeq]
UniProt Code:Q9Y6A5
NCBI GenInfo Identifier:5454102
NCBI Gene ID:10460
NCBI Accession:NP_006333.1
UniProt Related Accession:Q2NKK4,Q8IX09,Q9Y6A5
Molecular Weight:90,522 Da
NCBI Full Name:transforming acidic coiled-coil-containing protein 3
NCBI Synonym Full Names:transforming, acidic coiled-coil containing protein 3
NCBI Official Symbol:TACC3  
NCBI Official Synonym Symbols:ERIC1; ERIC-1; MGC117382; MGC133242  
NCBI Protein Information:transforming acidic coiled-coil-containing protein 3; OTTHUMP00000113796
UniProt Protein Name:Transforming, acidic coiled-coil containing protein 3
Protein Family:Transforming acidic coiled-coil-containing protein
UniProt Gene Name:TACC3  
UniProt Entry Name:Q2NKK4_HUMAN

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