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Anti-TIMM50 Antibody (CAB1536)

SKU:
CAB1536
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TIM50
TIM50L
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:TIMM50 Rabbit mAb
Product Code:CAB1536
Size:20uL, 50uL, 100uL
Synonyms:TIM50, TIM50L
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TIMM50
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, Mouse liver, Mouse brain
Immunogen:A synthesized peptide derived from human TIMM50
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:92609
Uniprot:Q3ZCQ8
Cellular Location:Mitochondrion inner membrane, Nucleus speckle, Single-pass membrane protein
Calculated MW:36kDa
Observed MW:38kDa
UniProt Protein Function:TIMM50: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. Belongs to the TIM50 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Mitochondrial; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex; mitochondrion; nuclear speck; nucleoplasm

Molecular Function:interleukin-2 receptor binding; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; ribonucleoprotein binding

Biological Process: mitochondrial membrane organization and biogenesis; protein amino acid dephosphorylation; protein import into mitochondrial matrix; release of cytochrome c from mitochondria

NCBI Summary:This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016]
UniProt Code:Q3ZCQ8
NCBI GenInfo Identifier:83305924
NCBI Gene ID:92609
NCBI Accession:Q3ZCQ8.2
UniProt Secondary Accession:Q3ZCQ8,Q330K1, Q6QA00, Q96FJ5, Q96GY2, Q9H370,
UniProt Related Accession:Q3ZCQ8
Molecular Weight:27,579 Da
NCBI Full Name:Mitochondrial import inner membrane translocase subunit TIM50
NCBI Synonym Full Names:translocase of inner mitochondrial membrane 50
NCBI Official Symbol:TIMM50  
NCBI Official Synonym Symbols:TIM50; TIM50L  
NCBI Protein Information:mitochondrial import inner membrane translocase subunit TIM50
UniProt Protein Name:Mitochondrial import inner membrane translocase subunit TIM50
Protein Family:Mitochondrial import inner membrane translocase
UniProt Gene Name:TIMM50  
UniProt Entry Name:TIM50_HUMAN

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