Anti-TPMT Antibody (CAB20922)
- SKU:
- CAB20922
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Plant
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-TPMT Antibody (CAB20922) |
| Antibody SKU: | CAB20922 |
| Antibody Size: | 50µL, 100µL |
| Application: | Western blotting |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of Human TPMT. |
| Application: | Western blotting |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, HepG2, K-562, Mouse liver, Mouse brain, Mouse kidney, Rat liver, Rat kidney |
| Immunogen: | Recombinant protein of Human TPMT. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 28kDa |
| Observed MW: | 32KDa |
| Synonyms: | TPMT, TPMTD |
| Background: | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. |
 | Western blot analysis of extracts of various cell lines, using TPMT antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. |
Related Products
Human Anti-Apolipoprotein Antibody / AAHA ELISA Kit
€599
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
€599
Mouse ACCPA / anti-cyclic citrullinated peptide antibody ELISA Kit
€649