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Anti-USP14 Antibody (CAB19589)

SKU:
CAB19589
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TGT
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

Product Name:USP14 Rabbit mAb
Product Code:CAB19589
Size:20uL, 50uL, 100uL
Synonyms:TGT
Applications:WB, IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human USP14
Applications:WB, IP
Recommended Dilutions:WB 1:500 - 1:2000 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HCT116, U-251MG, Mouse brain, Rat Brain
Immunogen:A synthesized peptide derived from human USP14
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9097
Uniprot:P54578
Calculated MW:56kDa
Observed MW:56KDa
UniProt Protein Function:USP14: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
UniProt Protein Details:

Protein type:EC 3.4.19.12; Ubiquitin conjugating system; Protease; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: cell surface; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; proteasome complex; synapse

Molecular Function:cysteine-type endopeptidase activity; endopeptidase inhibitor activity; protein binding; tRNA guanylyltransferase activity; ubiquitin-specific protease activity

Biological Process: protein deubiquitination; regulation of chemotaxis; synaptic transmission; ubiquitin-dependent protein catabolic process

NCBI Summary:This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P54578
NCBI GenInfo Identifier:82880645
NCBI Gene ID:9097
NCBI Accession:NP_001032411.1
UniProt Secondary Accession:P54578,Q53XY5, B7Z4N8, J3QRZ5,
UniProt Related Accession:P54578
Molecular Weight:60.1 kDa
NCBI Full Name:ubiquitin carboxyl-terminal hydrolase 14 isoform b
NCBI Synonym Full Names:ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
NCBI Official Symbol:USP14  
NCBI Official Synonym Symbols:TGT  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase 14
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase 14
UniProt Synonym Protein Names:Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14
Protein Family:Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name:USP14  
UniProt Entry Name:UBP14_HUMAN

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