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APC Anti-Human CD16 Antibody [3G8] (AGEL2479)

Datasheet MSDS
SKU AGEL2479
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG1, κ
Clone 3G8
Conjugation APC
€113 - €413

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Human CD16 Antibody [3G8]

The APC Anti-Human CD16 Antibody (3G8) offered by Assay Genie is an essential tool for researchers studying the CD16 antigen, a key molecule involved in immune responses. This monoclonal antibody, engineered for specificity and sensitivity, targets the CD16 protein found on the surface of human cells, particularly natural killer cells and macrophages, allowing for precise detection and analysis in flow cytometry and immunofluorescence applications.CD16, also known as FcγRIII receptor, plays a pivotal role in antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, crucial mechanisms in the immune system's defense against pathogens and tumor cells.

Understanding the functions and regulatory pathways of CD16 is imperative for advancing knowledge in immunology, infectious diseases, and cancer research.With its high affinity and reliability, the APC Anti-Human CD16 Antibody (3G8) from Assay Genie is a valuable asset for scientists investigating immune cell interactions, therapeutic antibody efficacy, and immune-related disorders. Trust in this antibody to deliver accurate and reproducible results, advancing your research endeavors in the realm of immunology and beyond.

Product Title:APC Anti-Human CD16 Antibody [3G8]
SKU:AGEL2479
Size:20 Tests, 100 Tests, 200 Tests
Clone No:3G8
Synonyms:FcγRIII;Fc gamma receptor;Fc gamma receptor 3;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P08637 O75015
Gene ID:941
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD16 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD16 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD16 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD16 appears to be expressed later in the immune response than CD86. CD16 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.
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