Description

Purified Anti-Human CD16 Antibody [3G8]

The Purified Anti-Human CD16 Antibody (3G8) offered by AssayGenie is a high-quality research tool designed for investigators studying CD16, a crucial cell surface receptor involved in immune responses, particularly in antibody-dependent cellular cytotoxicity (ADCC). This antibody is purified and optimized for use in various experimental applications, such as flow cytometry and immunohistochemistry, providing accurate and reliable detection of CD16 expression in human samples.CD16, also known as FcγRIII, is a key receptor found on various immune cells, including natural killer cells and macrophages, that plays a pivotal role in initiating immune responses against pathogens and tumor cells by mediating the destruction of target cells.

The Purified Anti-Human CD16 Antibody (3G8) specifically targets and binds to CD16, allowing for precise identification and analysis of CD16-expressing cell populations in research settings.With its high specificity and sensitivity, this antibody is an invaluable tool for researchers investigating immune cell function, immune-mediated diseases, and therapeutic strategies targeting CD16 signaling pathways. By enabling the accurate detection and manipulation of CD16 activity, this antibody supports advancements in immunology, oncology, and drug development research aimed at enhancing our understanding of immune responses and improving treatment outcomes.

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Product Title:	Purified Anti-Human CD16 Antibody [3G8]
SKU:	AGEL3348
Size:	25µg, 100µg
Clone No:	3G8
Synonyms:	FcγRIII;Fc gamma receptor;Fc gamma receptor 3;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM;Block

Isotype:	Mouse IgG1, κ
Isotype Control:	Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	Unconjugated
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	P08637 O75015
Gene ID:	941
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD16 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD16 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD16 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD16 appears to be expressed later in the immune response than CD86. CD16 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Purified Anti-Human CD16 Antibody [3G8] (AGEL3348)

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Description