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Purified Anti-Human CD16 Antibody [3G8] (AGEL3348)

SKU:
AGEL3348
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Block
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
3G8
Conjugation:
Unconjugated
€129 - €219
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Title:Purified Anti-Human CD16 Antibody [3G8]
SKU:AGEL3348
Size:25µg, 100µg
Clone No:3G8
Synonyms:FcγRIII;Fc gamma receptor;Fc gamma receptor 3;
Host Species:Mouse
Reactivity:Human
Application:FCM;Block
Isotype:Mouse IgG1, κ
Isotype Control:Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P08637 O75015
Gene ID:941
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD16 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD16 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD16 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD16 appears to be expressed later in the immune response than CD86. CD16 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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