ApoB Rabbit Polyclonal Antibody (CAB1330)
- SKU:
- CAB1330
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | ApoB Rabbit Polyclonal Antibody |
SKU: | CAB1330 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-330 of human ApoB (NP_000375.3). |
Sequence: | NSLN IAGL SLDF SSKL DNIY SSDK FYKQ TVNL QLQP YSLV TTLN SDLK YNAL DLTN NGKL RLEP LKLH VAGN LKGA YQNN EIKH IYAI SSAA LSAS YKAD TVAK VQGV EFSH RLNT DIAG LASA IDMS TNYN SDSL HFSN VFRS VMAP FTMT IDAH TNGN GKLA LWGE HTGQ LYSK FLLK AEPL AFTF SHDY KGST SHHL VSRK SISA ALEH KVSA LLTP AEQT GTWK LKTQ FNNN EYSQ DLDA YNTK DKIG VELT GRTL ADLT LLDS PIKV PLLL SEPI NIID ALEM RDAV EKPQ EFTI VAF |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | FLDB; FCHL2; LDLCQ4; apoB-48; apoB-100; ApoB |
Positive Sample: | Mouse plasma,Rat plasma, |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Secreted. |
Calculated MW: | 516kDa |
Observed MW: | 250kDa/ |
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL), and is the ligand for the LDL receptor. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
Purification Method: | Affinity purification |
Gene ID: | 338 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |