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Anti-ASMT Antibody (CAB11840)

SKU:
CAB11840
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
€139 - €419
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Description

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Antibody Name:Anti-ASMT Antibody
Antibody SKU:CAB11840
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human ASMT
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human
Positive Samples:293
Immunogen:A synthetic peptide of human ASMT
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:438
Uniprot:P46597
Cellular Location:
Calculated MW:33kDa/38kDa/41kDa
Observed MW:52kDa
Synonyms:ASMT, ASMTY, HIOMT, HIOMTY
Background:This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
UniProt Protein Function:ASMT: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. Belongs to the methyltransferase superfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - tryptophan; EC 2.1.1.4; Methyltransferase

Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2

Cellular Component: cytosol

Molecular Function:acetylserotonin O-methyltransferase activity; identical protein binding; O-methyltransferase activity; protein homodimerization activity; S-methyltransferase activity

Biological Process: indolalkylamine biosynthetic process; melatonin biosynthetic process; translation

NCBI Summary:This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
UniProt Code:P46597
NCBI GenInfo Identifier:1170276
NCBI Gene ID:438
NCBI Accession:P46597.1
UniProt Secondary Accession:P46597,Q16598, Q5JQ72, Q5JQ73, B2RC33,
UniProt Related Accession:P46597
Molecular Weight:Calculated MW: 33kDa/38kDa/41kDaObserved MW: 52kDa
NCBI Full Name:Acetylserotonin O-methyltransferase
NCBI Synonym Full Names:acetylserotonin O-methyltransferase
NCBI Official Symbol:ASMT  
NCBI Official Synonym Symbols:ASMTY; HIOMT; HIOMTY  
NCBI Protein Information:acetylserotonin O-methyltransferase
UniProt Protein Name:Acetylserotonin O-methyltransferase
UniProt Synonym Protein Names:Hydroxyindole O-methyltransferase; HIOMT
Protein Family:Acetylserotonin O-methyltransferase
UniProt Gene Name:ASMT  
Anti-ASMT Antibody (CAB11840)Western blot analysis of extracts of 293 cells, using ASMT antibody (CAB11840). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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