Asunercept (Research-Grade) is a research-grade biosimilar monoclonal antibody targeting CD178. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Tumor necrosis factor ligand superfamily member 6 (CD178/FASLG) is a ~31 kDa protein. Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
Product Name:
Asunercept (Research-Grade)
SKU:
GXBS01188
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Receptor-binding FasL ectodomain
Isotype:
Fusion - [FAS (Fas cell surface death receptor, TNFRSF6, tumor necrosis factor receptor (TNFR) superfamily member 6, FAS1, APO-1, CD95)]2 - IGHG1 Fc (Fragment constant)
Reactivity:
Human
Applications:
ELISA, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
APG-101, 1450882-18-4
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fusion-[human activin receptor type 2-A (activin receptor type IIA, ACTR-IIA) extracellular domain (ECD) fragment (1-109) engineered varian]2-IgG1-Fc (Fragment constant)
