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Anti-ATP13A2 Antibody (CAB13083)

SKU:
CAB13083
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-ATP13A2 Antibody
Antibody SKU:CAB13083
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 67-210 of human ATP13A2 (NP_001135446.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A375, K-562, 22Rv1, Mouse brain, Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 67-210 of human ATP13A2 (NP_001135446.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WKPL WGVR LRLR PCNL AHAE TLVI EIRD KEDS SWQL FTVQ VQTE AIGE GSLE PSPQ SQAE DGRS QAAV GAVP EGAW KDTA QLHK SEEA KRVL RYYL FQGQ RYIW IETQ QAFY QVSL LDHG RSCD DVHR SRHG LSLQ DQMV RKAI
Gene ID:23400
Uniprot:Q9NQ11
Cellular Location:Lysosome, Membrane, Multi-pass membrane protein
Calculated MW:125kDa/128kDa
Observed MW:129kDa
Synonyms:ATP13A2, CLN12, HSA9947, KRPPD, PARK9, SPG78
Background:This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transporter, ion channel; EC 3.6.3.-; Transporter; Hydrolase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: autophagic vacuole; cell soma; integral to plasma membrane; late endosome; lysosomal lumen; lysosomal membrane; lysosome; multivesicular body; neuron projection; transport vesicle; vesicle

Molecular Function:cation-transporting ATPase activity; manganese ion binding; protein binding; zinc ion binding

Biological Process: cellular calcium ion homeostasis; cellular cation homeostasis; cellular iron ion homeostasis; cellular zinc ion homeostasis; positive regulation of protein secretion; protein amino acid autophosphorylation; regulation of autophagic vacuole size; regulation of endopeptidase activity; regulation of macroautophagy; zinc ion homeostasis

Disease: Kufor-rakeb Syndrome

NCBI Summary:This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
UniProt Code:Q9NQ11
NCBI GenInfo Identifier:14285364
NCBI Gene ID:23400
NCBI Accession:Q9NQ11.2
UniProt Secondary Accession:Q9NQ11,O75700, Q5JXY1, Q5JXY2, Q6S9Z9,
UniProt Related Accession:Q9NQ11
Molecular Weight:128,323 Da
NCBI Full Name:Probable cation-transporting ATPase 13A2
NCBI Synonym Full Names:ATPase 13A2
NCBI Official Symbol:ATP13A2  
NCBI Official Synonym Symbols:CLN12; KRPPD; PARK9; HSA9947  
NCBI Protein Information:probable cation-transporting ATPase 13A2
UniProt Protein Name:Probable cation-transporting ATPase 13A2
Protein Family:Probable cation-transporting ATPase
UniProt Gene Name:ATP13A2  
UniProt Entry Name:AT132_HUMAN
Anti-ATP13A2 Antibody (CAB13083)Western blot analysis of extracts of various cell lines, using ATP13A2 antibody (CAB13083) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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