ATP7B Antibody [L62/29 (Formerly sold as S62-29)] is a mouse monoclonal antibody directed against ATP7B, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and IP. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.
ATP7B is a copper-transporting P-type ATPase critical for maintaining systemic and neuronal copper balance. Working in tandem with ATP7A, ATP7B facilitates the sequestration of intracellular copper into the vesicular secretory pathway, enabling its export and preventing toxic accumulation. This function is essential for copper detoxification, particularly in the liver, where ATP7B mediates biliary copper excretion. ATP7B operates by using ATP hydrolysis to transport copper ions across cellular membranes. Three isoforms of the ATP7B gene have been identified: isoform A is expressed in the liver, kidney, and brain; isoform B is brain-specific; and the WND/140 kDa isoform localizes to mitochondria, suggesting a role in mitochondrial copper regulation and oxidative stress response. Mutations in ATP7B cause Wilson disease, a rare autosomal recessive disorder characterized by copper accumulation in the liver and brain. Neurological manifestations include tremors, dystonia, psychiatric disturbances, and cognitive decline—highlighting the protein’s importance in neural function and copper detoxification. In neuroscience, ATP7B is increasingly recognized for its role in protecting neurons from copper-induced oxidative damage, a contributing factor in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Dysregulation of ATP7B may exacerbate mitochondrial dysfunction and protein aggregation, linking copper imbalance to broader neurodegenerative mechanisms. As a key regulator of copper metabolism, ATP7B represents a promising target for therapeutic strategies aimed at restoring metal homeostasis in neurodegenerative disease. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
ATP7B Antibody [L62/29 (Formerly sold as S62-29)]
Product SKU:
STMA00114
Size:
100 µg
Target:
ATP7B
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
L62/29 (Formerly sold as S62-29)
Research Areas:
Neuroscience, Ion Channels, Cell Signaling
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, IP
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~160kDa in rat brain membrane preparations.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2
