Slo2.2 Antibody [N3/26 (Formerly sold as S3-26)] is a mouse monoclonal antibody directed against Slo2.2, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.
Slo2.2, a member of the Slo potassium channel family, is a sodium-activated potassium channel that contributes to the regulation of resting membrane potential and neuronal excitability. Unlike Slo1, Slo2.2 is activated by intracellular Na⁺ and Cl⁻, linking its activity to ionic homeostasis and metabolic state. This channel is thought to stabilize neuronal firing under conditions of high activity or metabolic stress, making it a potential modulator of excitotoxicity—a key feature of many neurodegenerative diseases. By dampening excessive excitability, Slo2.2 may protect neurons from calcium overload and oxidative damage. Although still under investigation, emerging evidence suggests that Slo2.2 dysfunction may contribute to the pathophysiology of epilepsy, ischemia, and neurodegenerative disorders such as ALS and Alzheimer’s disease. Its unique activation profile and role in maintaining neuronal stability position Slo2.2 as a novel target for neuroprotective strategies. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
Slo2.2 Antibody [N3/26 (Formerly sold as S3-26)]
Product SKU:
STMA00092
Size:
100 µg
Target:
Slo2.2
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
N3/26 (Formerly sold as S3-26)
Research Areas:
Neuroscience, Ion Channels, Potassium Channels, Calcium-Activated Potassium Channels
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, AM
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~140kDa. Weak human detection. Does not cross-react with KCNT2/Slo2.1/Slick.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 1168-1237 of rat Slo2.2 (Slack)
Immunogen Species:
Rat
Accession Number:
NP_068625
Gene ID:
2065-06-26 00:00:00
Swiss-Prot:
Q9Z258
Cellular Localization:
Cell Membrane
Alternative Names:
KCNT1, potassium channel subfamily T member 1, bA100C15.2, SLACK, KCa4.1, KIAA1422, FLJ41282
References:
1. Santi C.M., et al. (2006) J Neuroscience, 26(19): 5059-5068. 2. Yuan A., et al. (2003) Neuron 37: 765-773.
