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Anti-BGN Antibody (CAB5770)

SKU:
CAB5770
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-BGN Antibody
Antibody SKU:CAB5770
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 38-368 of human BGN (NP_001702.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart, Mouse skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 38-368 of human BGN (NP_001702.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DEEA SGAD TSGV LDPD SVTP TYSA MCPF GCHC HLRV VQCS DLGL KSVP KEIS PDTT LLDL QNND ISEL RKDD FKGL QHLY ALVL VNNK ISKI HEKA FSPL RKLQ KLYI SKNH LVEI PPNL PSSL VELR IHDN RIRK VPKG VFSG LRNM NCIE MGGN PLEN SGFE PGAF DGLK LNYL RISE AKLT GIPK DLPE TLNE LHLD HNKI QAIE LEDL LRYS KLYR LGLG HNQI RMIE NGSL SFLP TLRE LHLD NNKL ARVP SGLP DLKL LQVV YLHS NNIT KVGV NDFC PMGF GVKR AYYN GISL FNNP VPYW EVQP ATFR CVTD RLAI QFGN YKK
Gene ID:633
Uniprot:P21810
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:41kDa
Observed MW:43kDa
Synonyms:BGN, DSPG1, MRLS, PG-S1, PGI, SEMDX, SLRR1A, biglycan
Background:This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication.
UniProt Protein Function:BGN: May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; lysosomal lumen; transport vesicle; cell surface; Golgi lumen; extracellular region; sarcolemma

Molecular Function:glycosaminoglycan binding; extracellular matrix binding; extracellular matrix structural constituent

Biological Process: chondroitin sulfate metabolic process; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; chondroitin sulfate catabolic process; pathogenesis; blood vessel remodeling; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; dermatan sulfate biosynthetic process

NCBI Summary:The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]
UniProt Code:P21810
NCBI GenInfo Identifier:266762
NCBI Gene ID:633
NCBI Accession:P21810.2
UniProt Secondary Accession:P21810,P13247, D3DWU3,
UniProt Related Accession:P21810
Molecular Weight:368
NCBI Full Name:Biglycan
NCBI Synonym Full Names:biglycan
NCBI Official Symbol:BGN  
NCBI Official Synonym Symbols:PGI; DSPG1; PG-S1; SLRR1A  
NCBI Protein Information:biglycan; biglycan proteoglycan; bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; small leucine-rich protein 1A; dermatan sulphate proteoglycan I
UniProt Protein Name:Biglycan
UniProt Synonym Protein Names:Bone/cartilage proteoglycan I; PG-S1
Protein Family:Biglycan
UniProt Gene Name:BGN  
UniProt Entry Name:PGS1_HUMAN
Anti-BGN Antibody (CAB5770)Western blot analysis of extracts of mouse heart cells, using BGN antibody (CAB5770) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).

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