The Biotinylated Anti-TIM3 Antibody (HDLA044) is a valuable tool for researchers studying T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM3), a cell surface protein involved in immune regulation and tolerance. This antibody, raised in rabbits, has high affinity and specificity for TIM3 and is validated for use in various applications, including Western blot, immunoprecipitation, and flow cytometry.TIM3 is expressed on a subset of T cells and plays a critical role in regulating immune responses, particularly in the context of T-cell exhaustion and tolerance. Its interaction with ligands like galectin-9 and CEACAM-1 has been implicated in the modulation of immune function and the development of immune-related diseases, such as cancer and chronic infections.
By targeting TIM3 with this biotinylated antibody, researchers can detect and study the expression and function of TIM3 in different cell types and tissues, providing valuable insights into its role in immune regulation and its potential as a therapeutic target for immunotherapy. This antibody is an essential tool for studies in immunology, oncology, and autoimmune diseases, offering researchers a reliable means to investigate the complex mechanisms underlying immune dysfunction and tolerance.
SKU:
HDLA044
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM82
Synonyms:
HAVCR2, TIM3, TIMD3, FLJ14428, KIM3
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
