C1GALT1C1 Antibody (PACO44862)
- SKU:
- PACO44862
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | C1GALT1C1 Antibody (PACO44862) |
| Antibody SKU: | PACO44862 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human C1GALT1-specific chaperone 1 protein (30-190AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: C1GALT1C1 antibody at 3.97µg/ml. Lane 1: Mouse gonadal tissue. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 36 kDa. Observed band size: 36 kDa.. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO44862 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44862 at dilution of 1:100. |
| Background: | Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). |
| Synonyms: | C1GALT1-specific chaperone 1 (C38H2-like protein 1) (C38H2-L1) (Core 1 beta1,3-galactosyltransferase 2) (C1Gal-T2) (C1GalT2) (Core 1 beta3-Gal-T2) (Core 1 beta3-galactosyltransferase-specific molecular chaperone), C1GALT1C1, COSMC |
| UniProt Protein Function: | C1GALT1C1: Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). Defects in C1GALT1C1 are the cause of Tn syndrome (TNSYN). Tn syndrome is a rare autoimmune disease caused by somatic mutation in the C1GALT1C1 gene in which subpopulations of blood cells of all lineages carry an incompletely glycosylated membrane glycoprotein, i.e. the Tn antigen. Since leukocytes and platelets are affected as well as red cells, anemia, leukopenia and thrombocytopenia are features. Tn-polyagglutinability is sometimes associated with leukemia or is a preleukemic state. Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq24 Cellular Component: Golgi membrane; integral to membrane Molecular Function:protein binding; polypeptide N-acetylgalactosaminyltransferase activity Biological Process: platelet activation; protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; positive regulation of transferase activity; post-translational protein modification Disease: Tn Polyagglutination Syndrome |
| NCBI Summary: | This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q96EU7 |
| NCBI GenInfo Identifier: | 74751849 |
| NCBI Gene ID: | 29071 |
| NCBI Accession: | Q96EU7.1 |
| UniProt Secondary Accession: | Q96EU7,Q8WWS3, Q9NZX1, A8K246, |
| UniProt Related Accession: | Q96EU7 |
| Molecular Weight: | 36,382 Da |
| NCBI Full Name: | C1GALT1-specific chaperone 1 |
| NCBI Synonym Full Names: | C1GALT1-specific chaperone 1 |
| NCBI Official Symbol: | C1GALT1C1 |
| NCBI Official Synonym Symbols: | TNPS; COSMC; MST143; C1GALT2; HSPC067; C38H2-L1 |
| NCBI Protein Information: | C1GALT1-specific chaperone 1; C1Gal-T2; C38H2-like protein 1; beta 1,3-galactosyltransferase 2; core 1 beta1,3-galactosyltransferase 2; core 1 beta3-Gal-T2; core 1 beta3-galactosyltransferase-specific molecular chaperone |
| UniProt Protein Name: | C1GALT1-specific chaperone 1 |
| UniProt Synonym Protein Names: | C38H2-like protein 1; C38H2-L1; Core 1 beta1,3-galactosyltransferase 2; C1Gal-T2; C1GalT2; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone |
| Protein Family: | C1GALT1-specific chaperone |
| UniProt Gene Name: | C1GALT1C1 |
| UniProt Entry Name: | C1GLC_HUMAN |
Related Products
C1GALT1C1 Antibody (PACO44863)
€269
Anti-C1GALT1C1 Antibody (CAB7590)
€119 - €419
C1GALT1C1 Antibody (PACO08089)
€459
Anti-PD-L2 Antibody (MACO0624)
€379