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Anti-CALCA Antibody (MACO0553)

SKU:
MACO0553
Product Type:
Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Monoclonal Antibody
Conjugation:
Unconjugated
€379
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Description

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Product Name:Anti-CALCA Antibody
Product Sku:MACO0553
Size:50ug
Host Species:Mouse
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:50-1:500
Species Reactivity:Human
Immunogen:Recombinant Human PCT
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%,Protein G purified
Clonality:Monoclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:
Synonyms:PCT
Product ImageImmunohistochemical of paraffin-embedded human thyroid tissues using MACO0553 at dilution of 1:200
UniProt Protein Function:CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: extracellular region; extracellular space

Molecular Function:calcitonin receptor binding; identical protein binding; protein binding

Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity

NCBI Summary:This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
UniProt Code:P01258
NCBI GenInfo Identifier:322510018
NCBI Gene ID:796
NCBI Accession:P01258.2
UniProt Secondary Accession:P01258,Q13935, Q13937, Q52LX7, B7ZL39,
UniProt Related Accession:P01258,P06881
Molecular Weight:38.6kDa
NCBI Full Name:Calcitonin
NCBI Synonym Full Names:calcitonin related polypeptide alpha
NCBI Official Symbol:CALCA  
NCBI Official Synonym Symbols:CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I  
NCBI Protein Information:calcitonin; calcitonin gene-related peptide 1
UniProt Protein Name:Calcitonin
UniProt Synonym Protein Names:CalcitoninKatacalcinAlternative name(s):Calcitonin carboxyl-terminal peptide; CCP
UniProt Gene Name:CALCA  

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