Calcium Sensing Receptor Antibody is a rabbit polyclonal antibody directed against Calcium Sensing Receptor, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human. Purified by Peptide Affinity.
The Calcium-Sensing Receptor (CaSR), encoded by the CASR gene, is a G-protein-coupled receptor (GPCR) that plays a pivotal role in maintaining systemic calcium homeostasis. While traditionally studied in the parathyroid gland and kidneys, CaSR is increasingly recognized for its critical functions in the central nervous system (CNS), where it is expressed in neurons, astrocytes, and oligodendrocytes. In the brain, CaSR modulates synaptic transmission, neuronal excitability, and neuroinflammatory responses. It responds to extracellular calcium fluctuations and other polyvalent cations, influencing intracellular signaling cascades that regulate neurotransmitter release, glial activation, and cell survival. Dysregulation of CaSR signaling has been implicated in several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Notably, CaSR activation has been linked to increased production of amyloid-beta and tau hyperphosphorylation—key pathological features of Alzheimer’s disease. Additionally, CaSR-mediated signaling may exacerbate neuroinflammation and oxidative stress, contributing to neuronal damage and synaptic loss. Given its dual role in calcium sensing and neuroimmune modulation, CaSR represents a promising therapeutic target for neurodegenerative disease intervention. Pharmacological modulation of CaSR activity—using calcimimetics or calcilytics—offers potential strategies to restore calcium balance and mitigate neurodegenerative progression. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF
Purification:
Peptide Affinity Purified
Concentration:
1 mg/ml
Reactivity:
Human
Recommended Dilution:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~140 kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide from the N-terminal (1-100 aa) of Human calcium-sensing receptor (CASR)
Immunogen Species:
Human
Accession Number:
NP_000379.2
Gene ID:
846
Swiss-Prot:
P41180
Cellular Localization:
Cell Membrane | Multi-Pass Membrane Protein
Tissue Specificity:
Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
