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Anti-Calnexin Antibody (CAB4846)

SKU:
CAB4846
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CNX
IP90
P90
CANX
Research Area:
Immunology
  • Immunology Antibodies 3 Anti-Calnexin Antibody CAB4846
  • Immunology Antibodies 3 Anti-Calnexin Antibody CAB4846
€139 - €419
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Description

Product Name:Calnexin Rabbit mAb
Product Code:CAB4846
Size:20uL, 50uL, 100uL
Synonyms:CNX, IP90, P90, Calnexin, CANX, calnexin
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Calnexin
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, HepG2, K-562
Immunogen:A synthesized peptide derived from human Calnexin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:821
Uniprot:P27824
Cellular Location:Endoplasmic reticulum, Endoplasmic reticulum membrane, Melanosome, Single-pass type I membrane protein
Calculated MW:90kDa
Observed MW:90kDa
UniProt Protein Function:Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum.Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Calcium-binding; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; rough endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; dendritic spine; cell soma; membrane; axon; melanosome; ribosome

Molecular Function:ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; carbohydrate binding; glycoprotein binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging

NCBI Summary:This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
UniProt Code:P27824
NCBI GenInfo Identifier:543920
NCBI Gene ID:821
NCBI Accession:P27824.2
UniProt Secondary Accession:P27824,B2R5V8, B4DGP8, B4E2T8, D3DWQ3, D6R9K3,
UniProt Related Accession:P27824
Molecular Weight:55,598 Da
NCBI Full Name:Calnexin
NCBI Synonym Full Names:calnexin
NCBI Official Symbol:CANX  
NCBI Official Synonym Symbols:CNX; P90; IP90  
NCBI Protein Information:calnexin; major histocompatibility complex class I antigen-binding protein p88
UniProt Protein Name:Calnexin
UniProt Synonym Protein Names:IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
UniProt Gene Name:CANX  
UniProt Entry Name:CALX_HUMAN

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