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Anti-Caspase-14 Antibody (CAB9618)

SKU:
CAB9618
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Developmental Biology
$167 - $503
Frequently bought together:

Description

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Antibody Name:Anti-Caspase-14 Antibody
Antibody SKU:CAB9618
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Caspase-14
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Mouse thymus, A375, Mouse stomach, Rat lung, Rat stomach
Immunogen:A synthesized peptide derived from human Caspase-14
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23581
Uniprot:P31944
Cellular Location:
Calculated MW:28kDa
Observed MW:17KDa/28KDa/35KDa
Synonyms:ARCI12
Background:This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
UniProt Protein Function:CASP14: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin. Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum). Expressed in keratinocytes of hair shaft and sebaceous glands. In psoriatic skin only expressed at very low levels. Belongs to the peptidase C14A family.
UniProt Protein Details:

Protein type:EC 3.4.22.-; Protease

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: cytoplasm; keratin filament; nucleus

Molecular Function:cysteine-type endopeptidase activity

Biological Process: epidermis development; DNA damage response, signal transduction resulting in induction of apoptosis; keratinization; proteolysis

NCBI Summary:This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
UniProt Code:P31944
NCBI GenInfo Identifier:12231007
NCBI Gene ID:23581
NCBI Accession:P31944.2
UniProt Secondary Accession:P31944,O95823, Q3SYC9,
UniProt Related Accession:P31944
Molecular Weight:27,680 Da
NCBI Full Name:Caspase-14
NCBI Synonym Full Names:caspase 14, apoptosis-related cysteine peptidase
NCBI Official Symbol:CASP14  
NCBI Protein Information:caspase-14; CASP-14; apoptosis-related cysteine protease; caspase 14, apoptosis-related cysteine protease
UniProt Protein Name:Caspase-14
Protein Family:Caspase
UniProt Gene Name:CASP14  
UniProt Entry Name:CASPE_HUMAN
Anti-Caspase-14 Antibody (CAB9618)Western blot - Caspase-14 Rabbit mAb (CAB9618)

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