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Cathepsin B Monoclonal Antibody (CAB23039)

SKU:
CAB23039
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Cathepsin B Monoclonal Antibody
SKU:CAB23039
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 8-339 of human Cathepsin B.
Sequence:CCLL VLAN ARSR PSFH PLSD ELVN YVNK RNTT WQAG HNFY NVDM SYLK RLCG TFLG GPKP PQRV MFTE DLKL PASF DARE QWPQ CPTI KEIR DQGS CGSC WAFG AVEA ISDR ICIH TNAH VSVE VSAE DLLT CCGS MCGD GCNG GYPA EAWN FWTR KGLV SGGL YESH VGCR PYSI PPCE HHVN GSRP PCTG EGDT PKCS KICE PGYS PTYK QDKH YGYN SYSV SNSE KDIM AEIY KNGP VEGA FSVY SDFL LYKS GVYQ HVTG EMMG GHAI RILG WGVE NGTP YWLV ANSW NTDW GDNG FFKI LRGQ DHCG IESE VVAG IPRT DQYW EKI
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:100 - 1:500 IF/ICC,1:50 - 1:200
Synonyms:KWE; APPS; CPSB; RECEUP; Cathepsin B
Positive Sample:Hep G2
Conjugate:Unconjugated
Cellular Localization:Lysosome, Melanosome, Secreted, Extracellular space.
Calculated MW:38kDa
Observed MW:39-42kDa

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified.

Purification Method:Affinity purification
Gene ID:1508
Clone Number:ARC59069
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Hep G2 cells, using Cathepsin B Rabbit mAb (CAB23039) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Enhanced Kit (AbGn00021).Exposure time: 120s.

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