CBL Rabbit Polyclonal Antibody (CAB0732)
- SKU:
- CAB0732
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | CBL Rabbit Polyclonal Antibody |
SKU: | CAB0732 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-906 of human CBL (NP_005179.2). |
Sequence: | AATA SPQL SSEI ENLM SQGY SYQD IQKA LVIA QNNI EMAK NILR EFVS ISSP AHVA T |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:100 IF/ICC,1:100 - 1:500 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells |
Synonyms: | CBL2; NSLL; C-CBL; RNF55; FRA11B; CBL |
Positive Sample: | 293T,Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 100kDa |
Observed MW: | 120kDa/110kDa |
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Purification Method: | Affinity purification |
Gene ID: | 867 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |