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Anti-CCAR2 Antibody (CAB7126)

SKU:
CAB7126
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • ChIP Antibodies Anti-CCAR2 Antibody CAB7126
  • ChIP Antibodies Anti-CCAR2 Antibody CAB7126
  • ChIP Antibodies Anti-CCAR2 Antibody CAB7126
  • ChIP Antibodies Anti-CCAR2 Antibody CAB7126
  • ChIP Antibodies Anti-CCAR2 Antibody CAB7126
€139 - €419
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Description

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Antibody Name:Anti-CCAR2 Antibody
Antibody SKU:CAB7126
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 654-923 of human CCAR2 (NP_066997.3).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, HeLa, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 654-923 of human CCAR2 (NP_066997.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLRD DGEE EFAG AKLE DSEV RSVA SNQS EMEF SSLQ DMPK ELDP SAVL PLDC LLAF VFFD ANWC GYLH RRDL ERIL LTLG IRLS AEQA KQLV SRVV TQNI CQYR SLQY SRQE GLDG GLPE EVLF GNLD LLPP PGKS TKPG AAPT EHKA LVSH NGSL INVG SLLQ RAEQ QDSG RLYL ENKI HTLE LKLE ESHN RFSA TEVT NKTL AAEM QELR VRLA EAEE TART AERQ KSQL QRLL QELR RRLT PLQL EIQR VVEK ADSW VEKE EPAP SN
Gene ID:57805
Uniprot:Q8N163
Cellular Location:Cytoplasm, Nucleus
Calculated MW:102kDa/103kDa
Observed MW:100kDa
Synonyms:CCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC
Background:
UniProt Protein Function:DBC-1: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Apoptosis; RNA-binding; Mitochondrial; Tumor suppressor

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: nucleoplasm; spliceosome; mitochondrial matrix; nuclear chromatin; cytoplasm; nucleus

Molecular Function:enzyme inhibitor activity; protein binding; enzyme binding

Biological Process: positive regulation of apoptosis; RNA splicing; rhythmic process; regulation of protein stability; cell cycle; regulation of circadian rhythm; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of catalytic activity; mitochondrial fragmentation during apoptosis; mRNA processing; regulation of RNA elongation; response to DNA damage stimulus; response to UV

UniProt Code:Q8N163
NCBI GenInfo Identifier:85701135
NCBI Gene ID:57805
NCBI Accession:Q8N163.2
UniProt Secondary Accession:Q8N163,Q6P0Q9, Q8N3G7, Q8N8M1, Q8TF34, Q9H9Q9, Q9HD12 Q9NT55, A6NL03, B2RB79, D3DSR6,
UniProt Related Accession:Q8N163
Molecular Weight:923
NCBI Full Name:Cell cycle and apoptosis regulator protein 2
NCBI Synonym Full Names:cell cycle and apoptosis regulator 2
NCBI Official Symbol:CCAR2  
NCBI Official Synonym Symbols:DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967  
NCBI Protein Information:cell cycle and apoptosis regulator protein 2; p30 DBC protein; deleted in breast cancer 1; cell division cycle and apoptosis regulator protein 2
UniProt Protein Name:Cell cycle and apoptosis regulator protein 2
UniProt Synonym Protein Names:Cell division cycle and apoptosis regulator protein 2; DBIRD complex subunit KIAA1967; Deleted in breast cancer gene 1 protein; DBC-1; DBC.1; p30 DBC
Protein Family:Cell cycle and apoptosis regulator protein
UniProt Gene Name:CCAR2  
UniProt Entry Name:CCAR2_HUMAN
Anti-CCAR2 Antibody (CAB7126)Western blot analysis of extracts of various cell lines, using CCAR2 antibody (CAB7126) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-CCAR2 Antibody (CAB7126)Immunohistochemistry of paraffin-embedded rat brain using CCAR2 antibody (CAB7126) at dilution of 1:100 (40x lens).
Anti-CCAR2 Antibody (CAB7126)Immunohistochemistry of paraffin-embedded human rectal cancer using CCAR2 antibody (CAB7126) at dilution of 1:100 (40x lens).
Anti-CCAR2 Antibody (CAB7126)Immunohistochemistry of paraffin-embedded mouse brain using CCAR2 antibody (CAB7126) at dilution of 1:100 (40x lens).
Anti-CCAR2 Antibody (CAB7126)Immunofluorescence analysis of U2OS cells using CCAR2 antibody (CAB7126). Blue: DAPI for nuclear staining.

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